Reduced Risk of Hepatic Steatosis in HIV/HCV Coinfection With Cannabis Use

//Reduced Risk of Hepatic Steatosis in HIV/HCV Coinfection With Cannabis Use

Reduced Risk of Hepatic Steatosis in HIV/HCV Coinfection With Cannabis Use

In this study, exposure to antiretroviral agents such as stavudine, didanosine, or nevirapine was not found to be associated with steatosis.
In this study, exposure to antiretroviral agents such as stavudine, didanosine, or nevirapine was not found to be associated with steatosis.

Daily cannabis use was shown to be associated with a reduced risk for liver steatosis among individuals co-infected with HIV and hepatitis C, according to the results of a recent study published in the Journal of Viral Hepatitis.

In this analysis of patients from a French cohort of people co-infected with HIV and hepatitis C, the association of steatosis and cannabis use was evaluated. Ultrasound examination was used to determine the presence of steatosis, and self-administered questionnaires collected sociobehavioral data, including cannabis use frequency.

A total of 40.1% (n=336/838) of study participants had liver steatosis. Most participants did not use or only occasionally used cannabis (74.7%), followed by daily use (14.0%) or regular use (11.7%).

 

Daily cannabis use was more common among patients who were negative for steatosis compared with those who were positive (16.1% vs 10.7%; P =.08). After adjusting for body mass index, hazardous alcohol consumption, and current or lifetime use of lamivudine or zidovudine, daily cannabis use was correlated with a lower risk for steatosis (adjusted odds ratio [OR] 0.64; 95% CI, 0.42-0.99; P =.046).

Other factors associated with liver steatosis included high body mass index (adjusted OR 1.93; P =.02), current or lifetime exposure for lamivudine or zidovudine (adjusted OR 1.51; P =.01), and hazardous alcohol consumption (adjusted OR 1.73; P =.03).

Author:

Source: http://www.infectiousdiseaseadvisor.com/hepatitis/cannabis-protective-of-liver-steatosis-hiv-hcv-coinfection/article/707191/